TY - JOUR AU - Audu, Haruna J. AU - Abiodun, Oyindamola A. AU - Ayeni, Funmilola A. PY - 2019/11/14 Y2 - 2024/03/28 TI - Beneficial effects of a fermented maize product with its supernatant, Lactobacillus fermentum and Lactobacillus brevis in rat model of colitis JF - The North African Journal of Food and Nutrition Research JA - Nor. Afr. J. Food Nutr. Res. VL - 3 IS - 6 SE - Original Articles DO - 10.51745/najfnr.3.6.195-200 UR - https://www.najfnr.com/home/article/view/90 SP - 195-200 AB - <p class="font_8"><span class="color_15"><strong>Background:</strong> African fermented foods such as maize cereal (Ogi ) and its supernatant (Omidun) are reservoirs of beneficial lactobacilli and carboxylic acids. Based on their constituents, their beneficial effect in a rat model of 2,4,6-trinitrobenzene sulphonic (TNBS) acid-induced colitis was assessed in comparison with two lactobacilli in a rat model of colitis.&nbsp;<strong>Methods:</strong>&nbsp;Female Wistar rats were distributed into seven groups of 5 rats each; the rats were pretreated for 14 days prior to colitis induction with Ogi, Omidun, L. fermentum, L. brevis and 7 days post colitic induction. Colitis was induced by an intracolonic administration of TNBS. The response of the rats to treatment was assessed macroscopically and biochemically.&nbsp;<strong>Results:</strong>&nbsp;Treatment with the Dexamethasone, Ogi and Omidun resulted in a significant reduction in colonic damage score and weight/length ratio (p&lt;0.05). Treatment with Ogi, Omidun, L. brevis, and dexamethasone significantly prevented depletion of colonic glutathione and superoxide dismutase. The up-regulation of myeloperoxidase activity was inhibited in all treated colitic rats (p&lt;0.05). However, Ogi appears to produce a better protective effect than the other treatment groups.&nbsp;<strong>Conclusions:</strong>&nbsp;This study reports that Ogi protects Wistar rats against the deleterious effect of trinitrobenzene sulphonic acid better than pure lactobacilli strains.</span></p><p class="font_8"><span class="wixGuard">​</span></p> ER -