Relationship Between Trans Fatty Acid (TFA) Consumption and Development of Obesity and/or Diabetes

The primary objective of this project is twofold. First, it seeks to elucidate the mechanistic link between trans fatty acid (TFA) consumption and the pathogenesis of obesity and/or diabetes, focusing on the lipotoxic cascades induced by elaidic acid as a representative industrial TFA model. Second, it investigates a targeted phytotherapeutic intervention designed to mitigate these metabolic derangements and restore physiological homeostasis.

  • Amina Tires
    Department of Biology, Faculty of Life and Natural Sciences, Djillali Liabes University, P.O. Box 89, Sidi-Bel-Abbes

How to Cite

Tires, A. . (2018). Relationship Between Trans Fatty Acid (TFA) Consumption and Development of Obesity and/or Diabetes. The North African Journal of Food and Nutrition Research, 2(4), 91-92. https://doi.org/10.51745/najfnr.2.4.91-92

1. Girard, J. (2003). Rôle des acides gras libres dans la sécrétion et l'action de l'insuline : Mécanismes de la lipotoxicité [Role of free fatty acids in insulin secretion and action: Mechanisms of lipotoxicity]. Médecine Sciences, 19(8–9), 827–833. https://doi.org/10.1051/medsci/20031989827

2. McGarry, J. D. (2002). Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes, 51(1), 7–18. https://doi.org/10.2337/diabetes.51.1.7

3. McGarry, J. D. (1992). What if Minkowski had been ageusic? An alternative angle on diabetes. Science, 258(5083), 766–770. https://doi.org/10.1126/science.1439783

4. Randle, P. J., Kerbey, A. L., & Espinal, J. (1988). Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones. Diabetes/Metabolism Reviews, 4(7), 623–638. https://doi.org/10.1002/dmr.5610040702

5. Shulman, G. I. (2000). Cellular mechanisms of insulin resistance. The Journal of Clinical Investigation, 106(2), 171–176. https://doi.org/10.1172/JCI10583

6. Unger, R. H. (2003). The physiology of cellular liporegulation. Annual Review of Physiology, 65, 333–347. https://doi.org/10.1146/annurev.physiol.65.092101.142622

7. Unger, R. H. (1995). Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications. Diabetes, 44(8), 863–870. https://doi.org/10.2337/diab.44.8.863

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