Body composition, energy expenditure, and markers of hemolysis in adults with sickle cell disease
Copyright © 2022 Karen Cordovil, Marise Crivelli, Flávia dos Santos Barbosa Brito, Marcos Fleury
This work is licensed under a Creative Commons Attribution 4.0 International License.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Background: Historically, malnutrition is described in individuals with SCD. However, more recent studies have shown a change in the profile of the nutritional status and distribution of body composition of SCD patients, mainly adult individuals. Aims: To assess the body composition (BC), resting energy expenditure (REE), and the biomarkers of hemolysis in adults with sickle cell disease (SCD). Subjects and Methods: A cross-sectional observational study was performed with 64 individuals over 39 years old in the treatment from two reference centers for SCD located in the city of Rio de Janeiro, Brazil. The dual-energy X-ray absorptiometry (DXA) and indirect calorimetry were used to assess BC and REE, respectively. Blood levels of hemoglobin, reticulocytes, lactate dehydrogenase (LDH), leukocytes, platelets, total and direct bilirubin, total protein, and albumin were measured to assess the hemolysis and protein status. The descriptive and inferential analysis was composed of the different methods (one-way ANOVA with the multiple comparison test of Tukey, Student t-test, and Pearson's correlation coefficient). Were considered statistically significant when the p-values were ≤ 0.05. Results: Most participants with SCD were female sex, colored (brown/black), and mean age of 51.2 years old. The obesity prevalence was 70.7% according to the body fat (BF%), with a major mean among women (p < 0.0001). Men had a higher mean of lean mass (LM) (p=0.0005) and fat-free mass (FFM) (p=0.0007). There was no difference for REE in comparing the genotypes (p= 0.53), and genders (p=0.075). The hemolysis markers (LDH, reticulocytes, and TB) correlated inversely with BMI (p=0.013), FM (p=0.022), and FFM (p=0.034). Conclusions: The important change observed in body composition in people with sickle cell disease was characterized by a high percentage of fat body and a decrease in lean mass. The hemolysis markers LDH, reticulocytes, and BT correlated inversely with BMI, FM, and FFM indicating that high levels of hemolysis may affect nutritional status, without influencing the REE.
Keywords
How to Cite
Similar Articles
- Assessment of Antioxidant and Antibacterial Activity of Phoenix dactylifera L. Seed Extracts: Perspective for the Development of New Foods
- Dietary Patterns and Nutrient Intake of Pregnant Women in Afijio and Oyo East Local Government Areas of Oyo State, Nigeria
- Exploring the Interplay Between Social Media Addiction, Mindful Eating, Intuitive Eating, Orthorexia Nervosa, and Mental Health in Young Adults
- Screening of Five Lactobacillus Bacteria with Probiotic Properties from Indigenous Klila Cheese
- Impact of Lycopene Supplementation on the Physicochemical, and Microbiological Properties of Fresh Goat Cheese
- The Role of Nutrition in Strengthening Immune System Against Newly Emerging Viral Diseases: Case of SARS-CoV-2
- Amino acid profile and scores of some selected traditional diets commonly consumed in northwest zone, Nigeria
- Anthropometric, Dietary, and Nutritional Outcomes of Vegetarian and Vegan Diets in Childhood: A Narrative Review and Recommendations for Adequate Nutrition
- Overview on Main Nutrition-Related Diseases in Three Countries from North Africa
- Evaluation of Hematopoietic and Immune Toxicity in First-Generation (G1) Rats Following Maternal Thiacloprid Exposure During Gestation and Lactation, and the Protective Potential of Bitter Apricot Kernel Extract
You may also start an advanced similarity search for this article.
NAJFNR is licensed under 